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BioMed Research International
Volume 2016, Article ID 5683097, 6 pages
http://dx.doi.org/10.1155/2016/5683097
Review Article

The Preclinical Research Progress of Stem Cells Therapy in Parkinson’s Disease

1Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China
2Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China
3Department of Paediatrics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China
4Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China
5Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China
6Department of Cardiac Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China
7School of Nursing, Hebei Medical University, Shijiazhuang, Hebei, China
8Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

Received 14 August 2015; Accepted 21 April 2016

Academic Editor: Anelli Tiziana

Copyright © 2016 Jun Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Parkinson’s disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed.