Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China
Table 2
Association of SOX9 gene polymorphism with ONFH risk.
dbSNP ID
Position
Group
Genotype ()
MAF
Codominants (11 versus 12 versus 22)
Dominants 12 + 22 versus 11
Recessive 22 versus 11 + 12
Allele 2 versus 1
11
12
22
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
rs1042667 (A>C)
CC
AC
AA
Control
46
90
43
0.491
0.835
1.244 (0.658–2.352)
0.971 (0.756–1.246)
0.930 (0.714–1.212)
0.906 (0.676–1.213)
ONFH
51
92
39
0.467
0.937
0.502
0.815
0.930
0.508
rs12601701 (G>A)
Promoter
AA
GA
GG
Control
48
93
38
0.472
0.518
1.396 (0.737–2.644)
0.734 (0.452–1.194)
1.009 (0.582–1.749)
1.179 (0.879–1.581)
ONFH
61
85
36
0.431
0.571
0.306
0.213
0.974
0.271
values of deviation from Hardy-Weinberg equilibrium between the ONFH and control groups. region. regression analyses were used for calculations. 11: homozygotes for the major allele, 12: heterozygotes, and 22: homozygotes for the minor allele.
