Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China
Table 3
Association of SOX9 gene polymorphisms with ONFH subgroups.
dbSNP
Subgroup
MAF
Allele (2 versus 1)
Codominant (11 versus 12 versus
Dominant (12 + 22 versus 11)
Recessive (22 versus 11 + 12)
11
12
22
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
rs1042667 (A>C)
AA
AC
CC
9
25
11
0.478
0.946
0.814
1.059
0.812
1.125
0.568
0.967
0.863
(0.596~1.503)
(0.662~1.692)
(0.751~1.684)
(0.662~1.413)
19
35
14
0.463
1.198
0.370
0.861
0.694
0.964
0.903
0.894
0.535
(0.807~1.780)
(0.408~1.817)
(0.135~1.736)
(0.627~1.274)
11
30
26
0.462
0.656
0.040
1.843
0.073
0.404
0.772
1.376
0.047
(0.437~0.982)
(0.945~3.593)
(0.420~1.418)
(1.005~1.883)
rs12601701 (G>A)
GG
GA
AA
Ster
9
23
13
0.456
1.069
0.779
1.053
0.896
1.014
0.968
1.038
0.939
(0.672~1.699)
(0.481~2.283)
(0.519~1.980)
(0.721~1.496)
Alc
16
30
22
0.456
1.067
0.747
1.637
0.161
0.658
0.168
1.212
0.242
(0.715~1.586)
(0.821~3.624)
(0.363~1.192)
(0.878~1.672)
Idio
11
26
30
0.358
1.410
0.095
1.790
0.085
0.757
0.370
1.343
0.065
(0.941~2.113)
(0.922~3.476)
(0.412~1.391)
(0.982~1.835)
: Alcohol-induced; Ster: steroid- induced; Idio: idiopathic; : homozygotes for the major allele; 12: heterozygotes; and 22: homozygotes for the minor allele. regression analyses were used. Bold: value < 0.05.
