Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China

Table 5

Association of the rs1042667 and rs12601701 genotypes of SOX9 gene with the clinical phenotypes of ONFH.

dbSNP	Genotype	Sex test		Disease course; (months) ANOVA test	Etiological classification; (%) test			Unilateral or bilateral hips lesions; (%) test		Clinical stage; (%) test
		Men; (%)	Women; (%)		Alc	Ster	Idio	Unilateral	Bilateral	Stage II	Stage III	Stage IV
rs1042667	AA	30 (23.8)	9 (16.1)	86.72 + 74.80	19 (27.9)	9 (20.0)	11 (16.4)	14 (17.7)	25 (24.5)	2 (15.4)	10 (19.2)	26 (23.2)
	AC	63 (50.0)	29 (51.8)	66.66 + 72.85	35 (51.5)	25 (55.6)	30 (44.8)	39 (49.4)	52 (51.0)	8 (61.5)	30 (57.7)	52 (46.4)
	CC	33 (26.2)	18 (32.1)	71.88 + 62.21	14 (20.6)	11 (24.4)	26 (38.8)	26 (32.9)	25 (24.5)	3 (23.1)	12 (23.1)	34 (30.4)
		0.450		0.332	0.131			0.352		0.646
rs12601701	AA	41 (32.6)	20 (35.7)	65.13 + 60.99	22 (32.4)	13 (28.9)	26 (38.8)	36 (45.6)	25 (24.5)	3 (23.1)	20 (38.5)	36 (32.2)
	AG	59 (46.8)	26 (46.4)	72.42 + 73.97	30 (44.1)	23 (51.1)	30 (44.8)	32 (40.5)	52 (51.0)	7 (53.8)	25 (48.0)	51 (45.5)
	GG	26 (20.6)	10 (17.9)	84.94 + 77.19	16 (23.5)	9 (20.0)	11 (16.4)	11 (13.9)	25 (24.5)	3 (23.1)	7 (13.5)	25 (22.3)
		0.874		0.411	0.729			0.009		0.636