Significant Associations of SOX9 Gene Polymorphism and Gene Expression with the Risk of Osteonecrosis of the Femoral Head in a Han Population in Northern China

Table 6

Haplotypes association of the SOX9 gene with hips lesions and clinical stages of ONFH.

Clinical phenotypes	Subtype	rs1042667(A), rs12601701(A)			rs1042667(A), rs12601701(G)			rs1042667(C), rs12601701(A)			rs1042667(C), rs12601701(G)
		(%)		OR (95% CI)	(%)		OR (95% CI)	(%)		OR (95% CI)	(%)		OR (95% CI)
Hip lesions	Unilateral	14.09 (8.9)	0.032	0.377 (0.150–0.947)	52.91 (33.5)	0.013	1.722 (1.120–2.647)	89.91 (56.9)	0.048	0.657 (0.432–0.997)	1.09 (0.7)	0.073	5.317 (0.703–40.228)
	Bilateral	7.24 (3.6)			94.73 (46.4)			94.73 (46.4)			7.27 (3.6)
Clinical stages	Stage IV	10.30 (4.6)	0.041	0.408 (0.408–0.987)	93.70 (41.8)	0.457	1.198 (0.743–1.932)	112.70 (50.3)	0.786	0.937 (0.589–1.493)	7.30 (3.3)	0.063	—
	Stage III	11.00 (10.6)			39.00 (37.5)			54.00 (51.9)			0.00 (0)