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BioMed Research International
Volume 2016, Article ID 5697571, 9 pages
Clinical Study

Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis

1Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
2Department of Pediatrics, The First People’s Hospital of Yongkang, Jinhua, China
3Department of Pediatrics, The Affiliated Children’s Hospital of Zhejiang University Medical College, Hangzhou, China
4Department of Pediatrics, Hainan Provincial People’s Hospital, Haikou, China
5Department of Pediatrics, Zouping People’s Hospital, Binzhou, Shandong Province, China

Received 18 July 2016; Revised 3 September 2016; Accepted 20 September 2016

Academic Editor: Kota V. Ramana

Copyright © 2016 Hailong Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis for the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis. The patients were divided into the S. baicalensis and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. The median duration of fever, median time to NS involvement, and the number of patients with oral ulcers and/or vesicles, as well as skin rashes, were decreased in the S. baicalensis group compared with the ribavirin group. In addition, the EV71 viral loads were decreased in the S. baicalensis group, suggesting that S. baicalensis exerted more potent antiviral effects compared with ribavirin. The present study demonstrated that S. baicalensis was suitable for the treatment of severe HFMD in patients aged >1 year, since it was shown to rapidly relieve fever, attenuate oral lesions and rashes, and improve NS involvement. Furthermore, it was demonstrated to be relatively safe for topical application.