Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb

Figure 8

(a–e) Desmin-positive muscle fibers. Desmin staining with striations confirms the survival of myotubes and maturation into muscle fibers after implantation into the RPNI. (a and b) Normal rat muscle fibers. (c) RPNI muscle fibers after maturing inside acellular muscle coated with PEDOT. (d) RPNI muscle fibers after maturing inside acellular muscle. (e) RPNI muscle fibers after maturing inside silicone mesh. Muscle fibers myoblast-derived muscle fibers were found within all RPNI specimens regardless of scaffold material. (f) Example of peroneal nerve cross section at the entrance to the RPNI.

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