Oxidative Stress and Liver Morphology in Experimental Cyclosporine A-Induced Hepatotoxicity

Figure 1

Light microscope, H+E. (a) Control group. Liver architecture within normal limits. 400. (b) Olive oil group. Mild passive hyperaemia within the central vein. 200. (c)–(f) CsA group. (c) Passive hyperaemia within central veins with dilatation of hepatic sinusoids. 200. (d) Vacuolar degeneration of the cytoplasm of hepatocytes (arrows). 400. (e) Focal micro- and macrovesicular steatosis (arrows). 200. (f) Focal liver cells necrosis accompanied by mononuclear inflammatory infiltrates. Single eosinophilic cells with signs of apoptosis present (arrows). 400.

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