Oxidative Stress and Liver Morphology in Experimental Cyclosporine A-Induced Hepatotoxicity

Figure 2

Electron microscope. (a) Control group. Hepatocyte with normal ultrastructural appearance. 8000. (b–d) CsA group. (b) Hepatocyte with dilatation of endoplasmic reticulum with the formation of different sized vacuoles (arrow). 8000. (c) Marked swelling of mitochondria with the presence of giant mitochondria (arrows) with disruption of mitochondrial cristae. Shrunken nucleus with condensed chromatin present. 20000. (d) Apoptotic cell with markedly condensed chromatin and shrunken cytoplasm. 60000.

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