Research Article
Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese
Table 3
Allele and genotype frequencies in female AAU patients and female controls.
| Gene
| SNP | Allele and genotype | AAU+AS+ (female) | AAU+AS− (female) | Controls (female) | (AS+) | Pc (AS+) | OR (95% CI) | (AS−) | Pc (AS−) | OR (95% CI) |
| | JAK1 | rs310241 | C | 80 (33.3%) | 138 (29.6%) | 156 (28.7%) | 0.19 | NS | 1.24 (0.90–1.72) | 0.74 | NS | 1.05 (0.80–1.37) | | CC | 12 (10.0%) | 14 (6.0%) | 17 (6.2%) | 0.19 | NS | 1.67 (0.77–3.61) | 0.91 | NS | 0.96 (0.46–2.00) | | CT | 56 (46.7%) | 110 (47.2%) | 122 (44.9%) | 0.74 | NS | 1.08 (0.70–1.66) | 0.60 | NS | 1.10 (0.77–1.56) | | TT | 52 (43.3%) | 109 (46.8%) | 133 (48.9%) | 0.31 | NS | 0.80 (0.52–1.23) | 0.64 | NS | 0.92 (0.65–1.30) | | rs2780815 | G | 159 (78.7%) | 400 (87.0%) | 495 (85.3%) | 0.03 | NS | 0.64 (0.42–0.96) | 0.45 | NS | 1.15 (0.80–1.63) | | GG | 63 (62.4%) | 175 (76.1%) | 212 (73.1%) | 0.04 | NS | 0.61 (0.38–0.99) | 0.44 | NS | 1.17 (0.79–1.75) | | GT | 33 (32.6%) | 50 (21.7%) | 71 (24.5%) | 0.11 | NS | 1.50 (0.91–2.45) | 0.46 | NS | 0.86 (0.57–1.29) | | TT | 5 (5.0%) | 5 (2.2%) | 7 (2.4%) | 0.20 | NS | 2.11 (0.65–6.80) | 0.86 | NS | 0.90 (0.28–2.87) |
| | JAK2 | rs10758669 | A | 170 (73.9%) | 328 (67.5%) | 399 (72.3%) | 0.64 | NS | 1.09 (0.77–1.54) | 0.10 | NS | 0.80 (0.61–1.04) | | AA | 59 (51.3%) | 104 (42.8%) | 144 (52.2%) | 0.88 | NS | 0.97 (0.63–1.49) | 0.03 | NS | 0.69 (0.49–1.00) | | AC | 52 (45.2%) | 120 (49.4%) | 111 (40.2%) | 0.36 | NS | 1.23 (0.79–1.90) | 0.04 | NS | 1.45 (1.02–2.05) | | CC | 4 (3.5%) | 19 (7.8%) | 21 (7.6%) | 0.13 | NS | 0.44 (0.15–1.30) | 0.93 | NS | 1.03 (0.54–1.97) | | rs10975003 | C | 44 (20.6%) | 117 (25.8%) | 93 (17.9%) | 0.40 | NS | 1.19 (0.80–1.77) | 2.83 × 10−3 | 0.09 | 1.59 (1.17–2.17) | | CC | 2 (1.9%) | 11 (4.8%) | 8 (3.1%) | 0.52 | NS | 0.60 (0.13–2.87) | 0.32 | NS | 1.60 (0.63–4.06) | | CT | 40 (37.4%) | 95 (41.9%) | 77 (29.6%) | 0.15 | NS | 1.42 (0.88–2.28) | 4.83 × 10−3 | NS | 1.71 (1.18–2.49) | | TT | 65 (60.7%) | 121 (53.3%) | 175 (67.3%) | 0.23 | NS | 0.75 (0.47–1.20) | 1.59 × 10−3 | 0.052 | 0.55 (0.38–0.80) |
| | STAT1 | rs1547550 | C | 205 (86.9%) | 411 (88.6%) | 423 (87.0%) | 0.95 | NS | 0.99 (0.62–1.56) | 0.47 | NS | 1.16 (0.78–1.71) | | CC | 88 (74.6%) | 182 (78.4%) | 185 (76.1%) | 0.75 | NS | 0.92 (0.55–1.53) | 0.55 | NS | 1.14 (0.74–1.75) | | CG | 29 (24.6%) | 47 (20.3%) | 53 (21.8%) | 0.56 | NS | 1.17 (0.70–1.96) | 0.68 | NS | 0.91 (0.59–1.42) | | GG | 1 (0.8%) | 3 (1.3%) | 5 (2.1%) | 0.40 | NS | 0.41 (0.05–3.52) | 0.56 | NS | 0.65 (0.15–2.76) | | rs2066802 | C | 46 (20.4%) | 81 (17.4%) | 113 (21.2%) | 0.80 | NS | 0.95 (0.65–1.40) | 0.13 | NS | 0.78 (0.57–1.08) | | CC | 1 (0.9%) | 6 (2.6%) | 8 (3.0%) | 0.22 | NS | 0.29 (0.04–2.34) | 0.78 | NS | 0.86 (0.29–2.50) | | CT | 44 (38.9%) | 69 (29.6%) | 97 (36.3%) | 0.63 | NS | 1.12 (0.71–1.76) | 0.11 | NS | 0.74 (0.51–1.07) | | TT | 68 (60.2%) | 158 (67.8%) | 162 (60.7%) | 0.93 | NS | 0.98 (0.63–1.54) | 0.10 | NS | 1.37 (0.95–1.97) | | rs6718902 | C | 132 (60.0%) | 259 (54.2%) | 308 (53.8%) | 0.12 | NS | 1.29 (0.94–1.76) | 0.91 | NS | 1.01 (0.79–1.29) | | CC | 36 (32.7%) | 72 (30.1%) | 82 (28.7%) | 0.43 | NS | 1.21 (0.75–1.94) | 0.72 | NS | 1.07 (0.74–1.56) | | CT | 60 (54.5%) | 115 (48.1%) | 144 (50.3%) | 0.45 | NS | 1.18 (0.76–1.84) | 0.61 | NS | 0.92 (0.65–1.29) | | TT | 14 (12.7%) | 52 (21.8%) | 60 (21.0%) | 0.06 | NS | 0.55 (0.29–1.03) | 0.83 | NS | 1.05 (0.69–1.59) | | rs10199181 | A | 51 (24.8%) | 117 (26.1%) | 148 (25.2%) | 0.91 | NS | 0.98 (0.68–1.41) | 0.73 | NS | 1.05 (0.79–1.39) | | AA | 6 (5.8%) | 20 (8.9%) | 19 (6.5%) | 0.82 | NS | 0.90 (0.35–2.31) | 0.29 | NS | 1.42 (0.74–2.73) | | AT | 39 (37.9%) | 77 (34.4%) | 110 (37.4%) | 0.94 | NS | 1.02 (0.64–1.62) | 0.48 | NS | 0.88 (0.61–1.26) | | TT | 58 (56.3%) | 127 (56.7%) | 165 (56.1%) | 0.97 | NS | 1.01 (0.64–1.58) | 0.90 | NS | 1.02 (0.72–1.45) |
| | IRF1 | rs2070721 | A | 86 (40.6%) | 154 (33.9%) | 216 (34.3%) | 0.10 | NS | 1.31 (0.95–1.80) | 0.90 | NS | 0.98 (0.76–1.27) | | AA | 15 (14.2%) | 26 (11.5%) | 29 (9.2%) | 0.15 | NS | 1.63 (0.84–3.17) | 0.39 | NS | 1.28 (0.73–2.23) | | AC | 56 (52.8%) | 102 (44.9%) | 158 (50.2%) | 0.63 | NS | 1.11 (0.72–1.73) | 0.23 | NS | 0.81 (0.58–1.14) | | CC | 35 (33.0%) | 99 (43.6%) | 128 (40.6%) | 0.16 | NS | 0.72 (0.45–1.14) | 0.49 | NS | 1.13 (0.80–1.60) |
| | NOS2 | rs2297518 | A | 52 (20.5%) | 69 (15.2%) | 74 (15.7%) | 0.10 | NS | 1.39 (0.94–2.05) | 0.84 | NS | 0.96 (0.68–1.38) | | AA | 3 (2.4%) | 6 (2.6%) | 2 (0.8%) | 0.24 | NS | 2.83 (0.47–17.17) | 0.14 | NS | 3.18 (0.63–15.90) | | AG | 46 (36.2%) | 57 (25.2%) | 70 (29.7%) | 0.20 | NS | 1.35 (0.85–2.13) | 0.27 | NS | 0.80 (0.53–1.20) | | GG | 78 (61.4%) | 164 (72.2%) | 164 (69.5%) | 0.12 | NS | 0.70 (0.45–1.10) | 0.51 | NS | 1.14 (0.77–1.71) | | rs4795067 | A | 173 (73.9%) | 369 (75.9%) | 439 (77.8%) | 0.24 | NS | 0.81 (0.57–1.15) | 0.46 | NS | 0.90 (0.67–1.20) | | AA | 62 (53.0%) | 145 (59.7%) | 169 (59.9%) | 0.20 | NS | 0.75 (0.49–1.16) | 0.95 | NS | 0.99 (0.70–1.40) | | AG | 49 (41.9%) | 79 (32.5%) | 101 (35.8%) | 0.26 | NS | 1.29 (0.83–2.01) | 0.43 | NS | 0.86 (0.60–1.24) | | GG | 6 (5.1%) | 19 (7.8%) | 12 (4.3%) | 0.70 | NS | 1.22 (0.45–3.32) | 0.08 | NS | 1.91 (0.91–4.02) |
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OR = odds ratio; 95% CI = 95% confidence interval.
Pc = value adjusted by Bonferroni correction.
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