Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese

Table 4

Allele and genotype frequencies of SNPs in patients with AAU versus control subjects stratified by HLA-B27 status.

Gene	SNP	Allele and genotype	AAU; HLA-B27	Control		Pc	OR (95% CI)
JAK1	rs310241	C	324 (31.0%)	392 (27.5%)	0.06	NS	1.18 (1.00–1.41)
		CC	41 (7.9%)	45 (6.3%)	0.29	NS	1.27 (0.82–1.96)
		CT	242 (46.4%)	302 (42.4%)	0.16	NS	1.18 (0.94–1.48)
		TT	239 (45.7%)	366 (51.3%)	0.05	NS	0.80 (0.64–1.00)
	rs2780815	G	878 (86.2%)	1250 (87.5%)	0.35	NS	0.89 (0.70–1.13)
		GG	381 (74.8%)	548 (76.7%)	0.44	NS	0.90 (0.69–1.18)
		GT	116 (22.8%)	154 (21.6%)	0.61	NS	1.07 (0.82–1.41)
		TT	12 (2.4%)	12 (1.7%)	0.40	NS	1.41 (0.63–3.17)
JAK2	rs10758669	A	705 (65.9%)	980 (69.0%)	0.10	NS	0.87 (0.73–1.03)
		AA	220 (41.1%)	346 (48.7%)	0.08	NS	0.74 (0.59–0.92)
		AC	265 (49.5%)	288 (40.6%)	1.62 × 10^−3	0.053	1.44 (1.15–1.80)
		CC	50 (9.4%)	76 (10.7%)	0.43	NS	0.86 (0.59–1.25)
	rs10975003	C	251 (24.5%)	272 (21.2%)	0.05	NS	1.21 (1.00–1.47)
		CC	26 (5.1%)	28 (4.4%)	0.56	NS	1.18 (0.68–2.03)
		CT	199 (38.8%)	216 (33.5%)	0.06	NS	1.26 (0.99–1.60)
		TT	287 (56.1%)	399 (62.1%)	0.03	NS	0.77 (0.61–0.98)
STAT1	rs1547550	C	937 (87.2%)	1254 (87.8%)	0.67	NS	0.95 (0.75–1.21)
		CC	407 (75.8%)	555 (77.7%)	0.42	NS	0.90 (0.69–1.17)
		CG	123 (22.9%)	144 (20.2%)	0.24	NS	1.18 (0.90–1.54)
		GG	7 (1.3%)	15 (2.1%)	0.29	NS	0.62 (0.25–1.52)
	rs2066802	C	190 (19.3%)	288 (20.7%)	0.39	NS	0.91 (0.74–1.12)
		CC	15 (3.0%)	27 (3.9%)	0.44	NS	0.78 (0.41–1.48)
		CT	160 (32.5%)	234 (33.7%)	0.66	NS	0.95 (0.74–1.21)
		TT	318 (64.5%)	434 (62.4%)	0.47	NS	1.09 (0.86–1.39)
	rs6718902	C	584 (56.5%)	778 (54.5%)	0.33	NS	1.08 (0.92–1.27)
		CC	163 (31.5%)	209 (29.3%)	0.40	NS	1.11 (0.87–1.42)
		CT	258 (49.9%)	360 (50.4%)	0.86	NS	0.98 (0.78–1.23)
		TT	96 (18.6%)	145 (20.3%)	0.45	NS	0.90 (0.67–1.19)
	rs10199181	A	270 (27.2%)	397 (27.8%)	0.75	NS	0.97 (0.81–1.16)
		AA	43 (8.7%)	55 (7.7%)	0.55	NS	1.14 (0.75–1.73)
		AT	184 (37.1%)	287 (40.2%)	0.28	NS	0.88 (0.69–1.11)
		TT	269 (54.2%)	372 (52.1%)	0.47	NS	1.09 (0.87–1.37)
IRF1	rs2070721	A	356 (35.7%)	487 (34.1%)	0.40	NS	1.08(0.91–1.27)
		AA	61 (12.2%)	74 (10.4%)	0.30	NS	1.21 (0.84–1.73)
		AC	234 (47.0%)	339 (47.4%)	0.87	NS	0.98 (0.78–1.23)
		CC	203 (40.8%)	301 (42.2%)	0.63	NS	0.94 (0.75–1.19)
NOS2	rs2297518	A	194 (18.1%)	209 (16.2%)	0.21	NS	1.15 (0.93–1.42)
		AA	12 (2.3%)	12 (1.9%)	0.64	NS	1.21 (0.54–2.72)
		AG	170 (31.7%)	185 (28.6%)	0.24	NS	1.16 (0.90–1.49)
		GG	354 (66.0%)	450 (69.5%)	0.20	NS	0.85 (0.67–1.09)
	rs4795067	A	797 (74.3%)	1008 (76.1%)	0.35	NS	0.92 (0.76–1.10)
		AA	293 (54.6%)	382 (57.7%)	0.33	NS	0.89 (0.71–1.23)
		AG	211 (39.4%)	244 (36.9%)	0.37	NS	1.11 (0.88–1.41)
		GG	32 (6.0%)	36 (5.4%)	0.69	NS	1.10 (0.68–1.80)

OR = odds ratio; 95% CI = 95% confidence interval.
Pc = value adjusted by Bonferroni correction.