Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis

Figure 2

Evidence of skeletal muscle remodelling and motor neuron denervation. mRNA levels of α-actin (ACTA1) (a), acetylcholine receptor (CHRNA1) (b), glial derived neurotropic factor (GDNF) (c), and cyclin-dependent kinase 5 (CDK5) (d) at BL and 12 wk. compared to age-matched controls ( compared to BL). Asterisks indicate significant difference from controls; and .

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