Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis

Figure 5

NCAM in ALS. (a) NCAM mRNA transcript in ALS during disease progression compared to controls. (b and c) Immunohistochemical staining for NCAM (blue) showed positive fibres (arrows) and cells (arrowheads) in ALS, but no staining except for a few positive satellite cells in controls (d). Stereological analysis of (e) NCAM⁺ fibres () and (f) NCAM⁺ cells. Asterisk indicates significant difference from controls; . In (a) for ALS and for controls. In (b–f) for ALS. Scale bar = 50 μm.

(a)

(b)

(c)

(d)

(e)

(f)