Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model

Table 1

Effects of VPA on renal function and urinary biochemistry.

	SHAM; ()	IRI; ()	IRI + VPA; ()
BUN (mg/dL)	13 ± 1	145 ± 35	39 ± 11
Creatinine (mg/dL)	0.2 ± 0.0	2.7 ± 0.4	0.5 ± 0.1
FENa (%)	0.2 ± 0.1	4.9 ± 1	0.5 ± 0.1
FEK (%)	22 ± 3	129 ± 17	17 ± 1.4
Urinary protein/creatinine	1.85 ± 0.2	3.9 ± 0.8	2.18 ± 0.2

BUN: blood urea nitrogen; FENa: fractional excretion of sodium; FEK: fraction excretion of potassium; IRI: ischemia-reperfusion injury; VPA: valproic acid.
Results are expressed as mean ± SEM. versus SHAM and IRI + VPA.