Function, Role, and Clinical Application of MicroRNAs in Vascular Aging

Table 1

miRNAs implicated in ECs functions.

ECs	miRNAs	Targets	Reference
Cellular apoptosis
Inhibit	miR-21	PTEN	[13]
	miR-26a	TRPC6	[14]
	miR-126	PI3K/Akt	[15]
	miR-130a	MAP3K12	[16]
	miR-155	Unknown	[17]
	miR-221/222	Ets-1/caspase-7	[18]
	miR-495	CCL2	[19]
	let-7a/b	LOX-1	[20]
	let-7g	Caspase-3	[21]
Promote	miR-19b	Apaf1	[22]
	miR-132	SIRT1	[23]
	miR-200c	ZEB1	[24]
	miR-223	IGF-1	[25]
	miR-365	Bcl-2	[26]
	miR-US25-1	BRCC 3	[27]
Cellular senescence
Promote	miR- 22	Vasohibin-1	[28]
	miR-34a	SIRT1	[29]
	miR-146a	SIRT1	[30]
	miR-200c	ZEB1	[24]
	miR-217	SIRT1	[31]
Inhibit	miR-92a	Unknown	[32]
	let-7g	SIRT1	[33]
Cellular proliferation
Promote	miR-29a	HBP1	[34]
	miR-126-5p	Dlk1	[35]
	miR-487b	THBS1	[36]
	miR-495	CCL2	[19]
Inhibit	miR-21	RhoB	[37]
	miR-24	Sp1	[38]
	miR-34a	SIRT1	[29]
	miR-92a	SIRT1	[39]
	miR-101	mTOR	[40]
	miR-125a	Bcl-2	[41]
Cellular angiogenesis
Proangiogenesis	miR-92a	PTEN	[42]
	miR-126	Spred-1	[43]
Antiangiogenesis	miR-15a	FGF2 and VEGF	[44]
	miR-20a	MKK3	[45]
	miR-21	RhoB	[46]
	miR-351	STAT3	[47]
	miR-214,	XBP1	[48]
	miR-223	β1 integrin	[49]
	miR-221/222	c-Kit	[50]
	miR-106	STAT3	[51]
Cellular inflammation
Promote	miR-21	PPARα	[52]
	miR-92a	SOCS5	[53]
Inhibit	miR-30-5p	Ang2	[54]
	miR-126	VCAM-1	[55]
	miR-155	Ang II type 1 receptor	[56]
	miR-181b	NF-kB	[57]
	miR-663	SLC7A5 and NAV2	[58]
	let-7g	TGF-β	[33]

EC, endothelial cell; PTEN, phosphatase and TENsin homologue; PI3K: phosphatidylinositol 3-kinase; TRPC6: transient receptor potential canonical 6; MAPK: mitogen-activated protein kinase; Ets-1: E26 transformation-specific 1; CCL2: C–C motif chemokine 2; LOX-1: lectin-like low-density lipoprotein receptor 1; Apaf-1: apoptotic protease-activating factor; SIRT1: silent information regulator 1; ZEB1: zinc finger E-box-binding homeobox 1; IGF-1: insulin-like growth factor-1; BRCC 3: BRCA1-BRCA2-containing complex; HBP1: HMG box-containing protein-1; Dlk1: delta-like 1 homologue; THBS1: thrombospondin 1; Sp1: specificity protein 1; mTOR: mammalian target of rapamycin; FGF2: fibroblast growth factor; VEGF: vascular endothelial growth factor; MKK3: mitogen-activated protein kinase kinases 3; STAT3: signal transducer and activator of transcription 3; XBP-1, a key unfolded protein response transcription factor; PPARα: peroxisome proliferator-activated receptor-α; SOCS5: suppressor of cytokine signaling 5; VCAM-1: vascular cell adhesion molecule 1; NF-kB: nuclear factor-kappa B; TGF-β: tumor growth factor-β.