Review Article

Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review

Table 1

Demographic and clinical characteristics of RA patients and control groups.

Author and yearCountry⁢Sample size (% women/% men)Age in years (mean or Min–Max)DAS-28 (mean)Duration of disease (mean or Min–Max)
CasesControlsCasesControls

García-González et al., 2015 [27]Mexico10 (90/10) A, 19 (84/16) I41 (90/10)48 A, 48.5 I38.04.3 A, 2.1 I 7.0 y A, 2.0 y I
Thiele et al., 2015 [18]USA1720 (9.1/90.9)80 (NS)63.4NS3.912.4 y
Datta et al., 2014 [16]India36 (77.7/22.3)NS40NS5.611 m–24 y
Nakajima et al., 2014 [17]Japan152 (67.7/32.3)80 (42.5/57.5)63.159.23.514.3 y
Nzeusseu Toukap et al., 2014 [19]Belgium33 URA (NS), 33 TRA (NS)39 (NS)NSNS4.8 URA, 4.9 TRANS
Veselinovic et al., 2014 [28]Serbia52 (63.5/36.5)30 (63.2/36.8)52.454.23.65.7 y
Wang et al., 2014 [35]China100 (62/38)50 (68/32)55.752.55.37.0 y
Jacobson et al., 2012 [26]Australia35 (62.9/37.1)39 (61.5/38.5)62.962.8NSNS
Kundu et al., 2012 [33]India25 (80/20)10 (80/20)40.026.55.711 m–25 y
Kwaśny-Krochin et al., 2012 [29]Poland46 (85/15)50 (86/14)57.056.05.28.1 y
Mishra et al., 2012 [42]India36 (61.1/38.9)36 (69.4/30.6)49.749.6NSNS
Stamp et al., 2012 [20]New Zealand77 (71.4/28.6)120 (NS)54.7NS3.8 NS
Staroń et al., 2012 [21]Poland25 (84/16)35 (NS)NSNSNSNS
Alver et al., 2011 [31]Turkey52 (76.9/23.1)42 (73.8/26.2)49.248.5NSNS
Aryaeian et al., 2011 [34]Iran59 (64.4/35.6)59 (64.4/35.6)41.9 39.1NS8.2 y
Ediz et al., 2011 [25]Turkey25 (72/28) ACPA (+) 24 (76/24) ACPA (−) 54.456.24.1 ACPA (+), 3.4 ACPA (−)9.6 y ACPA (+), 8.1 y ACPA (−)
Hassan et al., 2011 [10]Egypt30 (100)30 (100)35.832.34.06.5 y
Karaman et al., 2011 [30]Turkey43 (74.4/25.6)30 (56.7/43.3)39.837.2NS4.2 y
Desai et al., 2010 [22]India40 (50/50)40 (NS)40–60 40–60 NSNS
Rho et al., 2010 [23]USA169 (NS)92 (NS)>18>18NSNS
Shah et al., 2011 [32]India30 (83.3/16.7)30 (90/10)24.226.74.55.0 y
Tetik et al., 2010 [24]Turkey20 (NS)20 (NS)4825NS11 y

A: active disease patients; I: inactive disease patients.
URA: untreated patients; TRA: treated patients.
ACPA: anti-citrullinated protein antibodies, DAS-28: Disease Activity Score, m: months, NS: not specified, y: years.