BioMed Research International / 2016 / Article / Tab 4 / Research Article
Evaluating the Primary Prevention of Ischemic Stroke of Oral Antithrombotic Therapy in Head and Neck Cancer Patients with Radiation Therapy Table 4 Cox proportional hazard model of ischemic stroke and transient ischemic attack in head and neck cancer patients with radiation therapy between oral antithrombotic therapy users and nonusers.
Variables Follow-up method I Follow-up method II Adjusted HR† 95% CI Adjusted HR† 95% CI Lower Upper Lower Upper User versus nonuser 1.214 0.776 1.898 0.3961 0.812 0.199 3.309 0.7712 Age (years) <45 1.000 — — — 1.000 — — — 45 to 54 2.509 1.954 3.221 <0.0001 2.503 1.949 3.214 <0.0001 55 to 64 3.561 2.742 4.625 <0.0001 3.567 2.746 4.634 <0.0001 65 to 74 4.498 3.357 6.028 <0.0001 4.403 3.279 5.912 <0.0001 ≥75 5.722 3.794 8.631 <0.0001 5.615 3.707 8.505 <0.0001 Gender Men 1.000 — — — 1.000 — — — Women 0.708 0.567 0.884 0.0023 0.708 0.567 0.885 0.0024 Comorbidity Hypertension 1.483 1.209 1.819 0.0002 1.492 1.215 1.832 0.0001 Diabetes mellitus 1.654 1.310 2.088 <0.0001 1.652 1.305 2.091 <0.0001 Dyslipidemia 0.821 0.588 1.145 0.2445 0.838 0.600 1.170 0.3000 Chronic kidney disease 1.146 0.508 2.583 0.7427 1.188 0.526 2.679 0.6788 Heart failure 0.993 0.485 2.032 0.9847 1.057 0.517 2.162 0.8799 Atrial fibrillation 2.467 1.369 4.444 0.0026 2.521 1.398 4.547 0.0021 Gastrointestinal ulcer 0.920 0.691 1.224 0.5659 0.926 0.696 1.233 0.5993 Ischemic heart disease 1.213 0.873 1.686 0.2500 1.224 0.877 1.710 0.2352 Peripheral vascular disease 0.924 0.229 3.723 0.9118 0.956 0.237 3.852 0.9496 Deep vein thrombosis 3.599 1.154 11.225 0.0274 3.761 1.206 11.724 0.0224 Prescribed drugs ACEI 1.697 1.038 2.775 0.0350 1.549 0.922 2.602 0.0981 ARB 1.983 1.066 3.688 0.0305 1.874 0.982 3.578 0.0568 Beta blocker 1.592 0.588 4.313 0.3603 1.631 0.602 4.420 0.3360 CCB 0.000 0.000 0.9530 0.000 0.000 0.9580 NSAIDs 0.929 0.781 1.105 0.4043 0.939 0.789 1.117 0.4773 PPI 0.772 0.431 1.381 0.3833 0.797 0.445 1.426 0.4447 Statin 1.225 0.296 5.066 0.7791 1.438 0.349 5.935 0.6153
HR, hazard ratio; CI, confidence interval; ACEI, angiotensin-converting-enzyme inhibitor; ARB, angiotensin II receptor blocker; CCB, calcium channel blocker; NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor.
