Research Article
Effect of Prophylactic Antifungal Protocols on the Prognosis of Liver Transplantation: A Propensity Score Matching and Multistate Model Approach
Table 1
Demographic data of the liver transplantation recipients (before and after matching).
| | | Before matching | After matching | | | No prophylaxis | Prophylaxis | value | No prophylaxis | Prophylaxis | value |
| | | 201 | 360 | | 201 | 201 | |
| | Age (median (IQR)) | 53.00 (47.00, 57.00) | 55.00 (48.00, 60.00) | 0.021 | 53.00 (47.00, 57.00) | 54.00 (48.00, 59.00) | 0.228 |
| | Age (%) | | | | | | | | ≤55 | 71 (35.3) | 123 (34.2) | 0.048 | 71 (35.3) | 69 (34.3) | 0.953 | | >55–60 | 101 (50.2) | 155 (43.1) | 101 (50.2) | 101 (50.2) | | >60 | 29 (14.4) | 82 (22.8) | 29 (14.4) | 31 (15.4) |
| | Sex (%) | | | | | | | | Male | 153 (76.1) | 264 (73.3) | 0.533 | 153 (76.1) | 160 (79.6) | 0.471 | | Female | 48 (23.9) | 96 (26.7) | 48 (23.9) | 41 (20.4) |
| | HCC (%) | | | | | | | | No | 112 (55.7) | 195 (54.2) | 0.79 | 112 (55.7) | 108 (53.7) | 0.764 | | Yes | 89 (44.3) | 165 (45.8) | 89 (44.3) | 93 (46.3) |
| | Viral hepatitis (%) | | | | | | | | None | 26 (12.9) | 78 (21.7) | 0.017 | 26 (12.9) | 29 (14.4) | 0.905 | | HBV | 126 (62.7) | 183 (50.8) | 126 (62.7) | 127 (63.2) | | HCV | 38 (18.9) | 84 (23.3) | 38 (18.9) | 33 (16.4) | | HBV + HCV | 11 (5.5) | 15 (4.2) | 11 (5.5) | 12 (6.0) |
| | Ascites (%) | | | | | | | | Mild/moderate (≦2000 mL) | 139 (69.2) | 256 (71.2) | 0.484 | 139 (69.2) | 138 (68.7) | 1 | | Massive (>2000 mL) | 62 (30.8) | 104 (28.9) | 62 (30.8) | 63 (31.3) |
| | Living donor (%) | | | | | | | | No | 64 (31.8) | 72 (20.0) | 0.002 | 64 (31.8) | 58 (28.9) | 0.588 | | Yes | 137 (68.2) | 288 (80.0) | 137 (68.2) | 143 (71.1) |
| | MELD score | | | | | | | | ≦20 | 130 (64.7) | 258 (71.7) | 0.104 | 130 (64.7) | 133 (66.2) | 0.834 | | >20 | 71 (35.3) | 102 (28.3) | 71 (35.3) | 68 (33.8) |
| | Fungal infection (%) | | | | | | | | No | 163 (81.1) | 315 (87.5) | 0.054 | 163 (81.1) | 178 (88.6) | 0.052 | | Yes | 38 (18.9) | 45 (12.5) | 38 (18.9) | 23 (11.4) |
| | Mortality (%) | | | | | | | | No | 119 (59.2) | 272 (75.6) | <0.001 | 119 (59.2) | 154 (76.6) | <0.001 | | Yes | 82 (40.8) | 88 (24.4) | 82 (40.8) | 47 (23.4) |
| | Propensity score (median (IQR)) | NA | NA | | 0.40 (0.32, 0.46) | 0.40 (0.32, 0.44) | 0.690 |
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IQR: interquartile range, HCC: hepatocellular carcinoma, and MELD: model for end-stage liver disease. Ascites was measured during the operation.
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