|
| PAS | Major components and autoantigen targets | Minor components and autoantigen targets | Genetic |
|
| I | Addison’s disease | 21-Hydroxylase | Gonadal failure | P450 side-chain cleavage enzyme, 17a-hydroxylase | AIRE gene mutations (chromosome 21) |
Chronic hypoparathyroidism
Chronic candidiasis
(at least 2 present) | Calcium-sensing receptor | Vitiligo | SOX9, SOX10, tyrosinase |
| | | | Alopecia | Tyrosine hydroxylase | |
| II | Addison’s disease (always present) | 21-Hydroxylase | Atrophic gastritis | H+/K+ pump ATPase | Polygenic inheritance (HLA-DR3, chromosome 6) |
| | | Pernicious anaemia | Intrinsic factor |
| Thyroid autoimmune diseases | TSH-receptor
Thyroid peroxidase
Thyroglobulin | Celiac disease | Transglutaminase |
| | | Autoimmune hepatitis | P450 (IID6, IA2) |
| Type 1 diabetes mellitus | Glutamic acid decarboxylase
Tyrosine-phosphatase
Insulin | Hypophysitis and so forth | 68, 49, 43 kD from human |
| III | Thyroid autoimmune diseases associated with endocrinopathy other than Addison’s disease | TSH-receptor
Thyroid peroxidase
Thyroglobulin | Celiac disease | Transglutaminase | Polygenic inheritance (HLA-DR3, chromosome 6) |
| Autoimmune hepatitis | P450 (IID6, IA2) |
| Myasthenia gravis and so forth | Acetylcholine receptor |
| IIIA | Autoimmune thyroiditis | Thyroid peroxidase | | |
| Type 1 diabetes mellitus | Glutamic acid decarboxylase
Tyrosine-phosphatase
Insulin | | |
| IIIB | Autoimmune thyroiditis | Thyroid peroxidase | | |
| Pernicious anaemia | Intrinsic factor | | |
| IIIC | Autoimmune thyroiditis | Thyroid peroxidase | | |
| Vitiligo | SOX9, SOX10, tyrosinase | | |
| Alopecia | Tyrosine hydroxylase | | |
| Other organ-specific autoimmune disease | | |
| IV | Combination of organ-specific autoimmune diseases that do not fall in the previous types | | Gonadal failure | P450 side-chain cleavage enzyme, 17a-hydroxylase | Polygenic inheritance (HLA-DR3, chromosome 6) |
| | Vitiligo | SOX9, SOX10, tyrosinase |
| | Alopecia | Tyrosine hydroxylase |
| | Atrophic gastritis | H+/K+ pump ATPase |
| | Pernicious anaemia | Intrinsic factor |
| | Celiac disease | Transglutaminase |
| | Autoimmune hepatitis | P450 (IID6, IA2) |
| | Hypophysitis and so forth | 68, 49, 43 kD from human |
|
