Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway
Emodin suppressed the proliferation, migration, and invasion property of A2780 and SK-OV-3cells. (a) SK-OV-3 cells and A2780 cells were treated with increased concentrations of emodin for up to 72 hours to examine the cell viability. 24 h: , ; 48 h: , , and ; 72 h: , , and . (b) Emodin inhibited A2780 and SK-OV-3 cells growth in the dose- and time-dependent fashion. , , and . (c) Representative transwell migration and invasion assay of SK-OV-3 cells and A2780 cells after treatment with emodin (200 magnification). (d) Emodin weakened migration and invasion capacity of A2780 and SK-OV-3 cells. , , and .