Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway
Emodin inhibited the EMT of EOC cells by ILK/GSK-3β signaling pathway. (a, c) A2780 and SK-OV-3 cells were treated with 10 μM SB216763 and exposed with or without emodin 20 μM for 48 hours. Protein levels of ILK, p-GSK-3β, GSK-3β, β-catenin, Slug, E-cadherin, and N-cadherin were shown. (b, d) Quantitative analyses of factors in SK-OV-3 cells shown in (a) and (c). , . , .