Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1<i>β</i>-Induced Inflammation and Apoptosis in Chondrocytes

<div>Characterization of microspheres by scanning electron microscopy. (a) Microspheres were spherical and ranged in size from 7 to 16 <i>μ</i>m. (b) The microsphere surface appeared to be loose and porous, and the internal structure was cell-like. With regard to the variation in composition and structure, there was a slight increase in the microsphere size from (c) CS-IL-1Ra to (d) HA-CS-IL-1Ra microspheres (scale bar, 5 <i>μ</i>m). IL-1Ra: interleukin-1 receptor antagonist; HA: hyaluronic acid; CS: chitosan.</div>

BioMed Research International

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Figure 1

Figure 1: Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1<i>β</i>-Induced Inflammation and Apoptosis in Chondrocytes 

Figure 1 | Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1β-Induced Inflammation and Apoptosis in Chondrocytes 