Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1<i>β</i>-Induced Inflammation and Apoptosis in Chondrocytes

<div>HA-CS-mediated release of IL-1Ra reduces IL-1<i>β</i>-induced chondrocyte apoptosis. (a) Apoptosis in various treatment groups was assessed by TUNEL staining and fluorescence microscopic analysis (magnification, ×200). Nuclei were counterstained with DAPI. (b) AIs were obtained by quantification of (a). Values were expressed as the mean ± standard deviation. IL-1Ra: interleukin-1 receptor antagonist; HA: hyaluronic acid; CS: chitosan; AI: apoptotic index; TUNEL: terminal deoxyribonucleotide transferase dUTP nick-end labeling.</div>

BioMed Research International

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Figure 5

Figure 5: Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1<i>β</i>-Induced Inflammation and Apoptosis in Chondrocytes 

Figure 5 | Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1β-Induced Inflammation and Apoptosis in Chondrocytes 