The Impact of Acute Matriptase Inhibition in Hepatic Inflammatory Models

Figure 2

Lack of cytotoxic effects of matriptase inhibitors. (a) 24 h incubation of HepK2 cells with MI-432, MI-441, MI-460, or MI-461 at 50 μM. Values represent average relative absorbance values of produced MTS formazan in metabolically active cells expressed in control values ± SEMs. No significant differences were found between control and cocultures exposed to matriptase inhibitors (). (b) HepK6 cocultures were treated with MI-432, MI-441, MI-460, or MI-461 at 50 μM for 24 h. Relative absorbance values expressed in control values ± SEMs are indicated. No significant differences were found between control and treated cocultures ().

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