Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 6381464, 14 pages
http://dx.doi.org/10.1155/2016/6381464
Research Article

Preparation and Characterization of Novel Perfluorooctyl Bromide Nanoparticle as Ultrasound Contrast Agent via Layer-by-Layer Self-Assembly for Folate-Receptor-Mediated Tumor Imaging

1Ningbo First Hospital, Ningbo Hospital of Zhejiang University, The First Affiliated Hospital of Ningbo Medical College of Ningbo University, Ningbo, Zhejiang 315010, China
2Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China
3Ningbo Medical College of Ningbo University, Ningbo, Zhejiang 315010, China

Received 23 March 2016; Revised 25 May 2016; Accepted 27 June 2016

Academic Editor: Changyang Gong

Copyright © 2016 Yue Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. A. Wickline and G. M. Lanza, “Nanotechnology for molecular imaging and targeted therapy,” Circulation, vol. 107, no. 8, pp. 1092–1095, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Li, Y. He, W. Sun et al., “Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging,” Biomaterials, vol. 35, no. 11, pp. 3666–3677, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Hussain and Q. T. Nguyen, “Molecular imaging for cancer diagnosis and surgery,” Advanced Drug Delivery Reviews, vol. 66, pp. 90–100, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. H.-D. Liang and M. J. K. Blomley, “The role of ultrasound in molecular imaging,” The British Journal of Radiology, vol. 76, no. 2, pp. S140–S150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Y. Shim and J. R. Lindner, “Cardiovascular molecular imaging with contrast ultrasound: principles and applications,” Korean Circulation Journal, vol. 44, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. N. Leeuwenburgh, M. J. Wiezer, B. M. Wiarda et al., “Accuracy of MRI compared with ultrasound imaging and selective use of CT to discriminate simple from perforated appendicitis,” British Journal of Surgery, vol. 101, no. 1, pp. e147–e155, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. M. P. Leal, S. Rivera-Fernández, J. M. Franco, D. Pozo, J. M. De La Fuente, and M. L. García-Martín, “Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging,” Nanoscale, vol. 7, no. 5, pp. 2050–2059, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. A. M. Lutz, S. V. Bachawal, C. W. Drescher, M. A. Pysz, J. K. Willmann, and S. S. Gambhir, “Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model,” Clinical Cancer Research, vol. 20, no. 5, pp. 1313–1322, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Yang, Z.-Y. Chen, and Y. Lin, “Advancement of targeted ultrasound contrast agents and their applications in molecular imaging and targeted therapy,” Current Pharmaceutical Design, vol. 19, no. 8, pp. 1516–1527, 2013. View at Google Scholar · View at Scopus
  10. N. Deshpande, A. Needles, and J. K. Willmann, “Molecular ultrasound imaging: current status and future directions,” Clinical Radiology, vol. 65, no. 7, pp. 567–581, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Theek, F. Gremse, S. Kunjachan et al., “Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging,” Journal of Controlled Release, vol. 182, no. 1, pp. 83–89, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. E. E. J. Marxer, J. Brüßler, A. Becker et al., “Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 77, no. 3, pp. 430–437, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Reinemann and B. Strehlitz, “Aptamer-modified nanoparticles and their use in cancer diagnostics and treatment,” Swiss Medical Weekly, vol. 144, Article ID w13908, 2014. View at Publisher · View at Google Scholar
  14. P. S. Low, W. A. Henne, and D. D. Doorneweerd, “Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases,” Accounts of Chemical Research, vol. 41, no. 1, pp. 120–129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. T. van Rooij, V. Daeichin, I. Skachkov, N. De Jong, and K. Kooiman, “Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy,” International Journal of Hyperthermia, vol. 31, no. 2, pp. 90–106, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. R. F. Mattrey, D. M. Long, F. Multer, R. Mitten, and C. B. Higgins, “Perfluoroctylbromide: a reticuloendothelial-specific and tumor-imaging agent for computed tomography,” Radiology, vol. 145, no. 3, pp. 755–758, 1982. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Diou, N. Tsapis, C. Giraudeau et al., “Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI,” Biomaterials, vol. 33, no. 22, pp. 5593–5602, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. J. N. Marsh, C. S. Hall, M. J. Scott et al., “Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 49, no. 1, pp. 29–38, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. C.-H. Wang, S.-T. Kang, Y.-H. Lee, Y.-L. Luo, Y.-F. Huang, and C.-K. Yeh, “Aptamer-conjugated and drug-loaded acoustic droplets for ultrasound theranosis,” Biomaterials, vol. 33, no. 6, pp. 1939–1947, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Niu, Q. Sun, J. Zhou, D. Cheng, and G. Hong, “Folate-functionalized polymeric micelles based on biodegradable PEG-PDLLA as a hepatic carcinoma-targeting delivery system,” Asian Pacific Journal of Cancer Prevention, vol. 12, no. 8, pp. 1995–1999, 2011. View at Google Scholar · View at Scopus
  21. L. E. Kelemen, “The role of folate receptor α in cancer development, progression and treatment: cause, consequence or innocent bystander?” International Journal of Cancer, vol. 119, no. 2, pp. 243–250, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. J. C. Fernandes, X. Qiu, F. M. Winnik et al., “Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies,” International Journal of Nanomedicine, vol. 7, pp. 5833–5845, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. B. P. Barnett, J. Ruiz-Cabello, P. Hota et al., “Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets,” Contrast Media & Molecular Imaging, vol. 6, no. 4, pp. 251–259, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. W. H. Cai, W. D. Deng, H. H. Yang, X. Chen, and F. Jin, “A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics,” International Journal of Pharmaceutics, vol. 436, no. 1-2, pp. 536–544, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. Y.-K. Kim, A. Minai-Tehrani, J.-H. Lee, C.-S. Cho, M.-H. Cho, and H.-L. Jiang, “Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer,” International Journal of Nanomedicine, vol. 8, pp. 1489–1498, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. C. C. Kyung, H. J. Ji, J. C. Hyun, O. J. Cheol, W. K. Sung, and T. G. Park, “Folate receptor-mediated intracellular delivery of recombinant caspase-3 for inducing apoptosis,” Journal of Controlled Release, vol. 108, no. 1, pp. 121–131, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Wang, P. Zhao, X. Liang et al., “Folate-PEG coated cationic modified chitosan—cholesterol liposomes for tumor-targeted drug delivery,” Biomaterials, vol. 31, no. 14, pp. 4129–4138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. P. R. Mishra, L. Al Shaal, R. H. Müller, and C. M. Keck, “Production and characterization of Hesperetin nanosuspensions for dermal delivery,” International Journal of Pharmaceutics, vol. 371, no. 1-2, pp. 182–189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. T. S. H. Leong, T. J. Wooster, S. E. Kentish, and M. Ashokkumar, “Minimising oil droplet size using ultrasonic emulsification,” Ultrasonics Sonochemistry, vol. 16, no. 6, pp. 721–727, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Guan, Y. Miao, L. Xu et al., “Injectable nimodipine-loaded nanoliposomes: preparation, lyophilization and characteristics,” International Journal of Pharmaceutics, vol. 410, no. 1-2, pp. 180–187, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Nii and F. Ishii, “Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides,” Colloids and Surfaces B: Biointerfaces, vol. 41, no. 4, pp. 305–311, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. J.-Y. Fang, C.-F. Hung, S.-C. Hua, and T.-L. Hwang, “Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: drug release and cytotoxicity against cancer cells,” Ultrasonics, vol. 49, no. 1, pp. 39–46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. L.-C. Peng, C.-H. Liu, C.-C. Kwan, and K.-F. Huang, “Optimization of water-in-oil nanoemulsions by mixed surfactants,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 370, no. 1–3, pp. 136–142, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Wulff-Pérez, A. Torcello-Gómez, M. J. Gálvez-Ruíz, and A. Martín-Rodríguez, “Stability of emulsions for parenteral feeding: preparation and characterization of o/w nanoemulsions with natural oils and Pluronic f68 as surfactant,” Food Hydrocolloids, vol. 23, no. 4, pp. 1096–1102, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. C. A. Fraker, A. J. Mendez, L. Inverardi, C. Ricordi, and C. L. Stabler, “Optimization of perfluoro nano-scale emulsions: the importance of particle size for enhanced oxygen transfer in biomedical applications,” Colloids and Surfaces B: Biointerfaces, vol. 98, no. 1, pp. 26–35, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Y. Levy, W. Schutze, C. Fuhrer, and S. Benita, “Characterization of diazepam submicron emulsion interface: role of oleic acid,” Journal of Microencapsulation, vol. 11, no. 1, pp. 79–92, 1994. View at Publisher · View at Google Scholar · View at Scopus
  37. R. S. Kalhapure and K. G. Akamanchi, “Oleic acid based heterolipid synthesis, characterization and application in self-microemulsifying drug delivery system,” International Journal of Pharmaceutics, vol. 425, no. 1-2, pp. 9–18, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Freitas, G. Hielscher, H. P. Merkle, and B. Gander, “Continuous contact- and contamination-free ultrasonic emulsification—a useful tool for pharmaceutical development and production,” Ultrasonics Sonochemistry, vol. 13, no. 1, pp. 76–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. K. Ariga, Y. M. Lvov, K. Kawakami, Q. Ji, and J. P. Hill, “Layer-by-layer self-assembled shells for drug delivery,” Advanced Drug Delivery Reviews, vol. 63, no. 9, pp. 762–771, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. F. Li, P. Biagioni, M. Finazzi, S. Tavazzi, and L. Piergiovanni, “Tunable green oxygen barrier through layer-by-layer self-assembly of chitosan and cellulose nanocrystals,” Carbohydrate Polymers, vol. 92, no. 2, pp. 2128–2134, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. P. D. Nallathamby, K. J. Lee, and X.-H. N. Xu, “Design of stable and uniform single nanoparticle photonics for in vivo dynamics imaging of nanoenvironments of zebrafish embryonic fluids,” ACS Nano, vol. 2, no. 7, pp. 1371–1380, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Yin, P. Wang, R. Zheng et al., “Nanobubbles for enhanced ultrasound imaging of tumors,” International Journal of Nanomedicine, vol. 7, pp. 895–904, 2012. View at Publisher · View at Google Scholar · View at Scopus