The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

Figure 1

The inverse regulation of the activation status of RhoJ and Cdc42 is modulated via VEGF-VEGFR2 and Sema3E-PlexinD1 signals. Cdc42 is activated by Arhgef 15, which stimulates Pak2 and Pak4 phosphorylation and lumen formation. RhoJ leads to suppression of Rac1 activation, which is associated with the sprouting of cell.