Efficiency of Human Epiphyseal Chondrocytes with Differential Replication Numbers for Cellular Therapy Products

Figure 8

Implantation of P3 cell (PDL 23). P3 (HEC #9, PDL 23) cell-implanted sites were analyzed at 7 weeks. Macroscopic examination showed the flattened and smaller nodules (11 mg in weight) with translucent whitish surface (a). Microscopic examination showed the cartilaginous tissue with tight adhesion to the mouse muscle tissue and reactions of foreign-body type giant cells (b). The nodule consisted of chondrocytes with spindle nuclei and narrow lacunae and a few hypertrophic cells (c) in myxomatous matrix. The matrix was focally positive for COL II (d) and diffusely positive for COL I in the cartilage (e).