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BioMed Research International
Volume 2016, Article ID 6453803, 6 pages
http://dx.doi.org/10.1155/2016/6453803
Research Article

Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy

1Division of Nephrology, Kaohsiung Municipal Feng-Shan Hospital, Kaohsiung, Taiwan
2Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan
3Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
4Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

Received 4 August 2016; Revised 17 October 2016; Accepted 14 November 2016

Academic Editor: Ramazan Akdemir

Copyright © 2016 Shang-Chih Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We examined the changes in circulating fibroblast growth factor 23 (FGF23) and Klotho concentrations in hemodialysis patients after parathyroidectomy (PTX). Methods. We enrolled a cohort of hemodialysis patients who received PTX. Postoperatively, patients received calcium supplements and/or vitamin D analogue (calcitriol) to maintain serum calcium within 7.0–8.0 mg/dL. Information on clinical parameters including bone-mineral metabolic variables was collected pre-PTX and on days 5 and 90 after PTX. Concomitantly, serum full-length FGF23 and α-Klotho levels were measured. The relationship between FGF23 and clinical parameters was analyzed by single linear regression. Results. Forty-six participants (33 women; 13 men) were enrolled in the study. Their mean age was 56.49 years. Serum FGF23 and α-Klotho concentrations were elevated on days 5 and 90 after PTX compared to baseline (). Serum FGF23 concentrations negatively correlated with serum calcium concentrations pre-PTX (Beta ; 0.0949; ), day 5 post-PTX (Beta ; 0.0982; ), and day 90 post-PTX (Beta ; 0.1528; ). Conclusions. There was no change in circulating FGF23 and Klotho concentrations after PTX in hemodialysis patients given postoperative calcium supplements and/or vitamin D analogue. Serum FGF23 concentrations pre-PTX and at days 5 and 90 after PTX were inversely related to serum calcium concentrations.