Early Developmental Low-Dose Methylmercury Exposure Alters Learning and Memory in Periadolescent but Not Young Adult Rats

Table 3

-statistics and values from statistical analyses for the OFT, ORT, MWM, and CTA in periadolescent (PND-40) and young adult rats (PND-90).

Task	PND-40		PND-90
	-statistic	value	-statistic	value
OFT, distance	F3,36 = 5.7	0.0027	F3,36 = 9.6	<0.0001
OFT, rearings	F3,36 = 6.8	0.0009	F3,36 = 10.6	<0.0001
ORT	F3,36 = 9.9	0.0002	F3,36 = 4.5	0.0095
MWM
Control	F4,45 = 11.32	<0.0001	F4,45 = 17.31	<0.0001
MK-801	F4,45 = 0.7188	0.5841	F4,45 = 1.997	0.1134
MeHg 250 µg/kg/day	F4,45 = 0.6753	0.6126	F4,45 = 18.71	<0.0001
MeHg 500 µg/kg/day	F4,45 = 1.641	0.1858	F4,45 = 6.344	0.0004
MWM,
Interaction	F12,1880 = 6.521	<0.0001	F12,1880 = 11.47	<0.0001
Time	F4,1880 = 73.20	<0.0001	F4,1880 = 252.8	<0.0001
Treatments	F4,1880 = 73.63	<0.0001	F4,1880 = 26.11	<0.0001
CTA, aversion index
Interaction	F12,112 = 1.004	0.4507	F12,112 = 1.95	0.0357
Time	F4,112 = 53.70	<0.0001	F4,112 = 307	<0.0001
Treatments	F3,112 = 13.60	<0.0001	F3,112 = 1.21	0.3258

OFT: open field test; ORT: object recognition test; MWM: Morris water maze; CTA: conditioned taste aversion.
Results from one-way ANOVA; Results from two-way ANOVA.