Evaluation of Two Methods for Determination of CD64 as a Diagnostic Marker of Infection in Critically Ill Adults

Table 4

Utility of CD 64 markers categorized according to the cutoff that for each method maximized specificity ensuring at least 90% sensitivity [actually 91.2% (95% CI 90.7–91.6%)].

	Method #1	Method #2
AUC	0.925 (0.853–0.997)	0.933 (0.872–0.995)
Cutoff	2.4	1.3
After categorization
TP	31	31
FP	12	7
TN	43	48
FN	3	3
Specificity	78.2% (77.6%–78.8%)	87.3% (86.9%–87.7%)
Kappa	0.66 (0.55–0.77)	0.77 (0.67–0.86)
Accuracy	83.2% (82.8%–3.5%)	88.8% (88.5%–89.0%)
PPV	72.1% (71.2%–73.0%)	81.6% (80.8%–82.4%)
NPV	93.5% (93.2%–93.7%)	94.1% (93.9%–94.3%)

AUC: area under the curve; TP: true positive; FP: false positive; TN: true negative; FN: false negative; PPV: positive predictive value; NPV: negative predictive value.