Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

Figure 2

Modes of operation of mNCX. The figure reports the prevalent modes of operation of mNCX. (a) shows the forward mode of operation of the exchanger, which is prevalent in physiological conditions. In this mode of operation, mNCX mediates the extrusion of calcium ions from mitochondrial matrix in exchange for sodium ions. (b) shows mNCX reverse mode of operation. In this mode of operation, the mitochondrial exchanger mediates the influx of calcium ions into the matrix and the extrusion of sodium ions. The figure has been entirely reproduced from Castaldo et al., 2009 [26], upon written authorization by the editor.

(a)

(b)