Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats

Figure 5

Effects of CIG on BDA-labeled axons passing through lesion epicenter in injured spinal cord. For the purpose of detecting the axon growth and passage through the lesion epicenter (LEp) in the spinal cord, BDA was injected into the sensorimotor cortex and the red nucleus at 10 dpi and then transmitted through the corticospinal tract and rubrospinal tract. (a) The representative images of BDA-labeled axons on parasagittal sections at the rostral and the caudal area within 1 mm from the edge of LEp in the injured spinal cord at 31 dpi are presented. Scale bar = 25 m. (b) The quantitative analysis for the percentage of BDA-labeled axons passing through the LEp. Data are presented as mean ± SEM from 3 rats in each group. , the SCI model group versus the sham control groups; , , CIG-treated groups versus the model group.

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