Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts

Figure 1

(a) Effect of rebamipide on human osteoclastogenesis. Rebamipide (0, 1, and 3 mM) dose-dependently inhibited the formation of human osteoclasts induced in the presence of sRANKL (30 ng/mL) and M-CSF (100 ng/mL). Immunohistological staining for CD51/61 (vitronectin receptors). (b) Effect of rebamipide on human osteoclastogenesis. . (c) XTT assay. The -axis represents % expression of XTT assay compared with N (negative control without adding rebamipide). Each colored bar represents each level of normal volunteers.

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