Cost-Effectiveness between Double and Single Fecal Immunochemical Test(s) in a Mass Colorectal Cancer Screening
Table 1
Odds ratio (OR) and 95% confidence interval (CI) of fecal immunochemical test (FIT) positive and compliance to colonoscopy by gender, age group, and FIT status in the Jiashan mass colorectal cancer screening program in China, 2007–2009.
Gender
Age
FIT
Participant
Positive
OR1 (95% CI)
OR2 (95% CI)
Colonoscopy
OR1 (95% CI)
OR2 (95% CI)
(%)
(%)
Men
Age <55
FIT1
6,435
219 (3.4)
1.00
182 (83.1)
1.00
FIT2
5,314
196 (3.7)
1.09 (0.89–1.32)
1.00
162 (82.7)
0.97 (0.58–1.62)
1.00
Both
5,302
62 (1.2)
0.34 (0.25–0.45)
0.31 (0.23–0.41)
54 (87.1)
1.37 (0.60–3.12)
1.42 (1.62–3.23)
Either
6,447
353 (5.5)
1.64 (1.38–1.95)
1.51 (1.27–1.81)
294 (83.3)
1.01 (0.65–1.59)
1.05 (0.66–1.66)
Age ≥55
FIT1
5,352
327 (6.1)
1.00
245 (74.9)
1.00
FIT2
4,589
253 (5.5)
0.90 (0.76–1.07)
1.00
196 (77.5)
1.15 (0.78–1.70)
1.00
Both
4,580
93 (2.0)
0.32 (0.25–0.40)
0.36 (0.28–0.45)
73 (78.5)
1.22 (0.70–2.13)
1.06 (0.60–1.89)
Either
5,361
487 (9.1)
1.54 (1.33–1.78)
1.71 (1.46–2.00)
368 (75.6)
1.04 (0.75–1.43)
0.90 (0.63–1.29)
Women
Age <55
FIT1
6,921
297 (4.3)
1.00
257 (86.5)
1.00
FIT2
5,918
224 (3.8)
0.88 (0.74–1.05)
1.00
198 (88.4)
1.54 (0.87–2.72)
1.00
Both
5,911
64 (1.1)
0.24 (0.19–0.32)
0.28 (0.21–0.37)
57 (89.1)
1.27 (0.54–2.97)
1.07 (0.44–2.59)
Either
6,928
457 (6.6)
1.58 (1.36–1.83)
1.80 (1.52–2.12)
398 (87.1)
1.05 (0.68–1.62)
0.89 (0.54–1.45)
Age ≥55
FIT1
5,667
304 (5.4)
1.00
237 (78.0)
1.00
FIT2
5,065
242 (4.8)
0.89 (0.74–1.05)
1.00
198 (81.8)
1.27 (0.83–1.95)
1.00
Both
5,049
82 (1.6)
0.29 (0.23–0.37)
0.33 (0.26–0.42)
66 (80.5)
1.17 (0.63–2.15)
0.92 (0.49–1.73)
Either
5,683
464 (8.0)
1.57 (1.35–1.82)
1.77 (1.51–2.08)
369 (79.5)
1.10 (0.77–1.56)
0.86 (0.58–1.28)
Men
All
FIT1
11,787
547 (4.6)
1.00
432 (79.0)
1.00
FIT2
9,903
449 (4.5)
0.98 (0.86–1.11)
1.00
358 (79.7)
1.05 (0.77–1.43)
1.00
Both
9,882
155 (1.6)
0.33 (0.27–0.39)
0.34 (0.28–0.40)
127 (81.9)
1.21 (0.76–1.91)
1.15 (0.72–1.84)
Either
11,808
841 (7.1)
1.58 (1.41–1.76)
1.62 (1.44–1.82)
663 (78.8)
0.99 (0.76–1.29)
0.95 (0.71–1.26)
Women
All
FIT1
12,588
600 (4.8)
1.0
494 (82.2)
1.0
FIT2
10,983
459 (4.2)
0.87 (0.77–0.99)
1.0
396 (85.0)
1.23 (0.88–1.70)
1.0
Both
10,960
145 (1.3)
0.27 (0.22–0.32)
0.31 (0.26–0.37)
123 (84.2)
1.16 (0.71–1.89)
0.95 (0.57–1.58)
Either
12,611
914 (7.2)
1.56 (1.40–1.74)
1.79 (1.60–2.01)
767 (83.3)
1.08 (0.82–1.42)
0.88 (0.65–2.20)
Total
FIT1
24,375
1,148 (4.7)
1.0
926 (80.7)
1.0
FIT2
20,886
915 (4.4)
0.93 (0.85–1.01)
1.0
754 (82.4)
1.12 (0.90–1.41)
1.0
Both
20,842
301 (1.4)
0.30 (0.26–0.34)
0.32 (0.28–0.37)
250 (83.1)
1.18 (0.84–1.64)
1.05 (0.74–1.48)
Either
24,419
1,762 (7.2)
1.57 (1.46–1.70)
1.70 (1.56–1.84)
1,430 (81.2)
1.03 (0.86–1.25)
0.92 (0.75–1.13)
FIT1, the first FIT; FIT2, the second FIT; OR1 using FIT1 as reference; and OR2 using FIT2 as reference.
