Skin-Derived Precursors against UVB-Induced Apoptosis via Bcl-2 and Nrf2 Upregulation

Figure 5

Effect of UVB irradiation on cell apoptosis/proliferation by TUNEL and Ki67 analysis. (a) Immunohistochemical analysis of Ki67-positive and TUNEL-positive expression in SKPs and FBs after UVB irradiation (magnification ×400). +: UVB irradiation; −: non-UVB irradiation. In the TUNEL assay and Ki67 immunostaining, nuclei in apoptotic cells and proliferating cells appear brown. (b) Quantitative analysis of TUNEL⁺ cells and Ki67⁺ cells in four groups. SKPs⁺: SKPs irradiated group; SKPs⁻: SKPs unirradiated group; FBs⁺: FBs irradiated group; FBs⁻: FBs unirradiated group. ; ; ns: no significance.

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