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BioMed Research International
Volume 2016 (2016), Article ID 6896279, 6 pages
http://dx.doi.org/10.1155/2016/6896279
Research Article

Paediatric Tuberculosis at a Referral Hospital in Istanbul: Analysis of 250 Cases

1Department of Pediatrics, Faculty of Medicine, Bezmialem Vakıf University, Istanbul, Turkey
2Department of Pediatrics, Bakirkoy Sadi Konuk Educational and Research Hospital, Istanbul, Turkey
3Department of Pediatrics, Private Liv Hospital, Istanbul, Turkey
4Department of Pediatrics, Kanuni Sultan Suleyman Educational and Research Hospital, Istanbul, Turkey

Received 15 December 2015; Revised 30 March 2016; Accepted 3 May 2016

Academic Editor: Frederick D. Quinn

Copyright © 2016 Ozden Turel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Tuberculosis (TB) still remains a growing public health problem globally. TB in children is often diagnosed clinically. Methods. We conducted a retrospective chart review of children with TB from November 2004 through December 2010 to determine the appropriateness of using contact history and diagnostic testing. Results. A total of 250 children with TB were identified. One hundred and sixty-two children had only pulmonary disease while 39 had features of both extrapulmonary and pulmonary TB. Mean age was 7.8 years. Thirty-six patients had known contacts. The index case/cases were first-degree relatives in 75%. Sixteen patients who were symptomless were yielded by contact investigation of newly identified TB cases. Tuberculin skin test positivity was 53.3%. Acid-fast bacilli smear positivity was 13.1%, and culture positivity was 18.7%. Twenty-six patients had histopathology of nonrespiratory specimens (lymph nodes and other tissues) showing granulomatous inflammation and caseous necrosis consistent with TB. Conclusions. Presence of contact history directed us to search for TB in children with nonspecific symptoms even if physical examinations were normal. Some children who were close contacts to TB cases were identified to have TB before development of symptoms.