A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma
Table 3
Five-gene functions in previous research.
Chromosomal
Start site
End site
Function
GPR128
chr3
100328433
100414323
Playing important role in the transduction of intercellular signals across the plasma membrane; related to weight gain and intestinal contraction frequency in mouse [13–16].
AGXT
chr2
240868479
240880502
Expressing proteins involved in glyoxylate detoxification in the peroxisomes; its mutation causes primary hyperoxaluria type I, a severe inborn error of metabolism [17–20].
CYTH3
chr7
6161776
6272644
Mediating the regulation of protein sorting and membrane trafficking; related to HCC (hepatocellular carcinoma) tissues and could serve as prognostic factor [21–24].
C10orf76
chr10
101845599
102056193
Currently unknown; a recent study suggested the loss of C10orf76 resulted in the upregulation of several genes [25–29].
TSPAN9
chr12
3077355
3286564
Mediating signal transduction events that play a role in the regulation of cell development, activation, growth, and motility; associated with adhesion receptors of the integrin family and regulates integrin-dependent cell migration [30–34].