A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma

Table 3

Five-gene functions in previous research.

	Chromosomal	Start site	End site	Function
GPR128	chr3	100328433	100414323	Playing important role in the transduction of intercellular signals across the plasma membrane; related to weight gain and intestinal contraction frequency in mouse [13–16].
AGXT	chr2	240868479	240880502	Expressing proteins involved in glyoxylate detoxification in the peroxisomes; its mutation causes primary hyperoxaluria type I, a severe inborn error of metabolism [17–20].
CYTH3	chr7	6161776	6272644	Mediating the regulation of protein sorting and membrane trafficking; related to HCC (hepatocellular carcinoma) tissues and could serve as prognostic factor [21–24].
C10orf76	chr10	101845599	102056193	Currently unknown; a recent study suggested the loss of C10orf76 resulted in the upregulation of several genes [25–29].
TSPAN9	chr12	3077355	3286564	Mediating signal transduction events that play a role in the regulation of cell development, activation, growth, and motility; associated with adhesion receptors of the integrin family and regulates integrin-dependent cell migration [30–34].