PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain

Figure 2

Brain regions showing decreased (blue) or increased (red) FDG brain uptake. -map was overlaid on the rat brain template. Decrease in brain glucose metabolism after chemotherapy at a threshold of , uncorrected (a) in the bilateral medial prefrontal cortices for the cyclophosphamide-treated group and (b) in the left medial prefrontal cortex and bilateral hippocampi for the doxorubicin-treated group compared to normal control. Increase of brain glucose metabolism after donepezil intervention at a threshold of , uncorrected (c) in the bilateral medial prefrontal cortices, bilateral hippocampi (L > R), bilateral medial hippocampi, and bilateral parietal cortices for the cyclophosphamide-treated group and (d) in the bilateral global area of the cortices including the frontal, parietal, and temporal cortices and bilateral hippocampi for the doxorubicin-treated group, when compared with the respective chemotherapy-treated groups without donepezil intervention.

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