Clinical Application of Antimicrobial Bone Graft Substitute in Osteomyelitis Treatment: A Systematic Review of Different Bone Graft Substitutes Available in Clinical Treatment of Osteomyelitis

Table 4

Levels of evidence and grades of recommendation.

Product name	Study	Level of evidence	Grade of recommendation
Osteoset-T	McKee et al. 2010 [19]	1b	B
	Gitelis and Brebach 2002 [20]	2b
	Ferguson et al. 2014 [31]	2b
	von Stechow et al. 2005 [21]	2b
	Chang et al. 2007 [22]	2b
	Humm et al. 2014 [32]	3b
	Tsai et al. 2004 [23]	4
Perossal	von Stechow and Rauschmann 2009 [24]	2b	C
	Berner et al. 2008 [25]	4
BonAlive	Drago et al. 2013 [26]	2b	C
	Lindfors et al. 2010 [27]	2b
	Romanò et al. 2014 [29]	2b
	McAndrew et al. 2013 [28]	3b
Herafill-G	Fleiter et al. 2014 [30]	3b	D
	Franceschini et al. 2012 [33]	4