Table 2: Age, scores, and results of laboratory parameters, of hemodynamic monitoring (PiCCO-System), and of dynamic measurement of the liver function (LiMON-System) at inclusion or on day 1 (before granulocyte therapy) of survivors and nonsurvivors (median/0.25–0.75 quartile).

Statistical significance ()

Age (years)59 (57–76)67 (66–72)n.s.
Surgery/no surgery4/15/0
APACHE II at ICU arrival/at inclusion20.5 (17.8–25)/22 (22–34)27 (27–33)/30 (28–32)n.s.
SOFA at inclusion8 (6–10)14 (13–14)n.s.
SAPS II at inclusion47 (44–62)74 (73–78)0.032
MODS at inclusion8 (7–12)12 (11–13)n.s.
Bilirubin (µmol/L)12 (11–17)44 (30–145)0.016
ALAT (U/L)32 (20–45)37 (30–219)n.s.
ASAT (U/L)62 (44–74)105 (52–669)n.s.
Ammonia (mmol/L)36 (32–62)39 (38–61)n.s.
PCT (ng/mL)7.3 (0.5–43)10.4 (7.4–14.6)n.s.
Leukocytes (GpT/L)18.1 (14.8–18.1)16.2 (13.9–22.2)n.s.
Thrombocytes (GpT/L)159 (89–278)125 (47–269)n.s.
Prothrombin time as INR1.09 (1.01–1.1)1.32 (1.11–1.33)n.s.
Activated partial thromboplastin time (s)36 (33–49)48 (45–54)n.s.
Creatinine (µmol/L)143 (79–238)178 (165–213)n.s.
Urea (mmol/L)15.7 (5.7–16)14.7 (13.8–24.9)n.s.
Lactate (mmol/L)1.0 (0.9–1.8)2.0 (1.6–2.1)n.s.
Complement C3 (g/L)1.1 (1.0–1.8)0.7 (0.5–1.0)n.s.
Complement C4 (g/L)0.5 (0.4–0.9)0.4 (0.2–0.5)n.s.
HLA-DR/CD-14 positive cells (expression/cell)6413 (5890–6970)8980 (7640–9590)n.s.
Cardiac index (L/m2/min)3.5 (3.3–4.0)2.5 (2.5–3.4)n.s.
Stroke volume index (mL/m2)48 (43–51)29 (28–39)n.s.
MAP (mmHg)92 (84–93)71 (69–85)n.s.
Norepinephrine (µg/kg/min)0.13 (0.06–0.21)0.36 (0.29–0.51)0.032
ICG-PDR on day 1 (%)/ICG-PDR/CI14.4 (13.3–17.2)/5.6 (4.9–5.7)5.3 (2.5–11.9)/2.9 (1.1–2.9)0.048/0.05

ALAT: alanine aminotransferase.
APACHE: Acute Physiology and Chronic Health Evaluation.
ASAT: aspartate aminotransferase.
CI: cardiac index.
HLA: human leukocyte antigen.
ICG-PDR: indocyanine green plasma disappearance rate.
MAP: mean arterial pressure.
MODS: multiorgan dysfunction syndrome (score).
n.s.: not (statistically) significant.
PCT: procalcitonin.
SAPS: simplified acute physiology score.
SOFA: sequential organ failure assessment (score).