Research Article

Influence of Botulinumtoxin A on the Expression of Adult MyHC Isoforms in the Masticatory Muscles in Dystrophin-Deficient Mice (Mdx-Mice)

Table 1

mRNA expression of MyHC isoforms (Myh1, Myh2, Myh4, and Myh7) in BTX-A treated and untreated muscle tissue, 21 days after injection into the right masseter muscle of 100-day-old mice (control/mdx; each). Means ± standard deviations; Student’s -test ⁢ treated versus untreated masseter muscle; ⁢ control versus mdx. Significant values are indicated by bold lettering.

Gene nameFibre typeMasseter rightMasseter leftTemporal rightTemporal leftTongue
ControlMdxControlMdxControlMdxControlMdxControlMdx

Myh 1IIx/d1.06 ± 0.711.65 ± 0.87

Myh 2IIa2.29 ± 0.791.23 ± 0.610.77 ± 0.59

Myh 4IIb1.18 ± 0.902.63 ± 1.572.99 ± 2.43

Myh 7I0.000133 ± 3.15E50.000053 ± 8.98E60.000113 ± 1.8E50.000261 ± 7.27E5