A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Figure 5

Breast cancer drug repositioning. Ten known drugs approved to treat breast cancer were obtained from the Maya Clinic, Cancer Org, and TTD. A total of 143 breast cancer-specific pathways were identified from multiple breast cancer expression profiles. Successfully mapped pathways and drugs were labeled as 1. Once labels were initialized on the pathway-drug network, we repositioned drugs for breast cancer using semisupervised learning. Predicted drugs with were considered promising candidate drugs, and their associations with breast cancer were investigated using two different validation methods.