A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Table 4

Breast cancer pathways from GSE2990 ().

#	Name	ES	NES	value
1	REACTOME_DEFENSINS	−0.767	−1.599	0.008230452
2	REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT	0.771	1.668	0.004016064
3	REACTOME_G0_AND_EARLY_G1	−0.771	−1.601	0.008213553
4	REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	−0.601	−1.670	0
5	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL	0.756	1.644	0.00617284
6	REACTOME_PECAM1_INTERACTIONS	−0.855	−1.685	0.001972387
7	REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION	0.773	1.558	0.003891051
8	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	−0.773	−1.613	0.008438818
9	BIOCARTA_GATA3_PATHWAY	0.746	1.688	0.002004008
10	REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE	0.709	1.747	0
11	BIOCARTA_G2_PATHWAY	−0.705	−1.704	0.00625
12	REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS	−0.757	−1.718	0.001865672
13	REACTOME_PYRIMIDINE_METABOLISM	−0.702	−1.726	0.001964637
14	BIOCARTA_ACTINY_PATHWAY	−0.734	−1.749	0.001945525
15	REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI	0.703	1.699	0.001976285
16	REACTOME_ENDOGENOUS_STEROLS	−0.762	−1.694	0.005703422
17	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	0.590	1.763	0.006048387

Supplementary files 2, 3, 4, and 5 provide the full pathway enrichment analysis results for the breast cancer expression profiles.