Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study
Table 6
Total ADRs collected from all patients.
ADR
TB with DM ()
TB without DM ()
value
ADR incidence (%)
Onset time, days (median, IQR)
ADR incidence (%)
Onset time, days (median, IQR)
Nausea and vomiting
13 (26.0)
12 (7–26)
50 (18.80)
14 (5–32)
0.242
Rashes
12 (24.0)
16 (10–29)
62 (23.31)
13 (5–45)
0.916
Peripheral neuropathy
18 (36.0)
17 (7–50)
62 (23.31)
15 (10–39)
0.058
Liver injury
11 (22.0)
25 (17–54)
48 (18.04)
32 (25–65)
0.510
Restlessness
21 (42.0)
10 (5–25)
48 (18.04)
08 (5–21)
<0.001
GI problem
07 (14.0)
12 (5–40)
23 (8.65)
16 (11–32)
0.236
Hypoglycemia
02 (4.0)
06 (3–10)
00
00
0.001
Joint pain#
07 (14.0)
20 (11–45)
32 (12.03)
14 (10–55)
0.698
Drowsiness
05 (10.0)
11 (5–27)
41 (15.41)
08 (3–21)
0.319
Back pain
07 (14.0)
37 (15–55)
09 (3.38)
22 (12–51)
0.002
Feet pain
05 (10.0)
30 (25–39)
06 (2.25)
21 (18–45)
0.006
Body ache
05 (10.0)
10 (7–18)
11 (3.48)
18 (10–24)
0.083
Blurring vision
01 (2.0)
60
03 (1.12)
55 (42–64)
0.613
Other nervous system disorders
20 (40.0)
08 (03–18)
74 (23.4)
06 (15–50)
0.084
Loss of appetite and diarrhea; sleep disorders, headache, irritability, and vertigo; #arthralgia and Achilles pain; ADR: adverse drug reaction; IQR: interquartile range; data were analyzed using chi square test. was considered as significant. ADR reported by TB with DM patients = 46; ADR reported by TB without DM patients = 178. , , and .
