Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study
Table 7
ADR incidence in different categories of TB patients with and without DM.
ADRs
Category I ()
Category II ()
TB with DM ()
TB without DM ()
value1
TB with DM ()
TB without DM ()
value2
value3
ADR incidence, (%)
ADR incidence, (%)
ADR incidence, (%)
ADR incidence, (%)
Nausea and vomiting
11 (26.8)
38 (17.7)
0.177
02 (22.2)
12 (23.07)
0.955
0.775
Rashes
10 (24.4)
43 (20.1)
0.534
02 (22.2)
19 (36.5)
0.404
0.890
Peripheral neuropathy
14 (34.1)
45 (21.0)
0.068
04 (44.4)
17 (32.7)
0.493
0.560
Liver injury
07 (17.1)
32 (15.0)
0.730
04 (44.4)
16 (30.8)
0.420
0.073
Restlessness
15 (36.6)
36 (16.8)
0.004
06 (66.6)
12 (23.1)
0.008
0.098
GI problem
05 (12.2)
18 (8.4)
0.438
02 (22.2)
05 (9.6)
0.273
0.432
Hypoglycemia
01 (2.4)
00
0.022
01 (11.1)
00
0.015
0.229
Joint pain
05 (12.2)
19 (8.9)
0.505
02 (22.2)
13 (25.0)
0.858
0.432
Drowsiness
05 (12.2)
31 (14.5)
0.700
00
10 (19.2)
0.150
0.269
Back pain
05 (12.2)
07 (3.3)
0.013
02 (22.2)
02 (3.9)
0.040
0.432
Feet pain
04 (9.7)
06 (2.8)
0.036
01 (11.1)
00
0.015
0.902
Body ache
04 (9.7)
07 (3.3)
0.061
01 (11.1)
04 (7.7)
0.730
0.902
Blurring vision
01 (2.4)
03 (1.4)
0.624
00
00
00
0.636
Other nervous system disorders
16 (39.0)
52 (24.3)
0.051
04 (44.4)
22 (42.3)
0.905
0.764
Data compared between TB with DM and TB without DM group in category I patients. 2Data compared between TB with DM and TB without DM group in category II patients. 3Data compared between TB with DM patients between category I and category II patients. ADR: adverse drug reaction; TB: tuberculosis; DM: diabetes mellitus; all data has been analyzed by chi square test; was considered as significant.
