BioMed Research International / 2016 / Article / Tab 3

Research Article

Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

Table 3

(a) The identities of genes resulting from the GEO analysis, along with their significance and function (derived from Gene Ontology and NCBI). Data is sorted by -score (ascending). As noted in the text, this is a sample of the 1,052 significant genes found across all datasets. (b) The identities of genes which were significant across more than one dataset within our GEO analysis, noting which sets they were significant within, their adjusted value in that set, and a broad functional class.
(a)

Dataset (GEO)ID value (adjusted)Gene symbol-scoreFunction (GO)

GSE65141423795_atSfpq−8.79DNA binding
GSE65141416332_atCirbp−7.93RNA binding
GSE65141442051_atHist2h3c1−7.68Negative regulation of transcription from RNA polymerase II promoter
GSE65141422660_atRbm3−7.63RNA binding
GSE65141452091_a_atRbm28−7.54RNA binding
GSE65141435854_atOpalin−7.41Molecular function
GSE65141427464_s_atHspa5−7.37ATP binding
GSE65141425993_a_atHsph1−7.23ATP binding
GSE65141424638_atCdkn1a−7.11Cyclin-dependent protein kinase
GSE65141454725_atTra2a−6.89RNA binding
GSE65141417574_atCxcl12−6.86Growth factor activity
GSE65141416749_atHtra1−6.84Insulin-like growth factor binding
GSE65141436094_atVgf−6.74Neuropeptide hormone activity
GSE65141420093_s_atHnrpdl−6.73DNA binding
GSE65141451566_atZfp810−6.68Metal ion binding
GSE65141416354_atRbmx−6.56RNA binding
GSE65141448654_atMtch2−6.53Transport
GSE65141439630_x_atSbsn−6.50Molecular function
GSE65141423796_atSfpq−6.48DNA binding
GSE65141441075_atNostrin−6.47DNA binding
GSE65141454014_a_atMkks−6.40ATP binding
GSE65141429862_atPla2g4e−6.38Phospholipase A2 activity
GSE65141428470_atExoc2−6.32Ral GTPase binding
GSE65141426722_atSlc38a2−6.28Amino acid transmembrane transporter activity
GSE65141448454_atSrsf6−6.22Negative regulation of mRNA splicing
GSE65141417303_atMvd−6.17ATP binding
GSE65141460645_atChordc1−6.12Hsp90 protein binding
GSE65141451047_atItm2a−6.09Integral membrane protein
GSE65141452318_a_atHspa1b−6.09NF-kappaB binding
GSE2871AF020212_s_atDnm1l−6.32Apoptosis, inferred
GSE65141417606_a_atCalr−6.08Androgen receptor binding
GSE65141452170_atChpf2−6.06Molecular function
GSE65141428112_atManf−6.06Growth factor activity
GSE65141435158_atRbm12b1−6.04RNA binding
GSE28701369751_at0.00002325TRHR thyrotropin releasing hormone receptor−6.17Thyrotropin releasing hormone receptor, GPCR signaling pathway
GSE2871rc_AI172162_at0.0000257Psmb4−6.01Negative regulation of inflammatory response to antigenic stimulus
GSE28701367851_at0.00005068Prostaglandin D2 synthase−6.00Regulation of circadian cycle
GSE23921427660_x_at0.00038711IGK-V28−6.04Response to lipopolysaccharide

(b)

Set 1ID (set 1) value (adjusted), set 1Gene symbolSet 2ID (set 2) value (adjusted), set 2Broad function

GSE9635670_atAtp1a3GSE2871D00189_atDystonia in mice

GSE65141438635_x_atB930041F14RikGSE19185ILMN_1250201Channel activity

GSE2871AF055884_s_atDeaf1GSE65141448446_atZinc finger transcriptional regulator, SPN

GSE9640422_atIGFBP2GSE19185ILMN_2930897Insulin-like growth factor binding protein

GSE65141422660_atRbm3GSE19185ILMN_1234453RNA binding

GSE9639756_g_atXbp1GSE65141437223_s_atMHC class 2 regulation

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