Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

Table 3

(a) The identities of genes resulting from the GEO analysis, along with their significance and function (derived from Gene Ontology and NCBI). Data is sorted by -score (ascending). As noted in the text, this is a sample of the 1,052 significant genes found across all datasets. (b) The identities of genes which were significant across more than one dataset within our GEO analysis, noting which sets they were significant within, their adjusted value in that set, and a broad functional class.

(a)

Dataset (GEO)	ID	value (adjusted)	Gene symbol	-score	Function (GO)
GSE6514	1423795_at		Sfpq	−8.79	DNA binding
GSE6514	1416332_at		Cirbp	−7.93	RNA binding
GSE6514	1442051_at		Hist2h3c1	−7.68	Negative regulation of transcription from RNA polymerase II promoter
GSE6514	1422660_at		Rbm3	−7.63	RNA binding
GSE6514	1452091_a_at		Rbm28	−7.54	RNA binding
GSE6514	1435854_at		Opalin	−7.41	Molecular function
GSE6514	1427464_s_at		Hspa5	−7.37	ATP binding
GSE6514	1425993_a_at		Hsph1	−7.23	ATP binding
GSE6514	1424638_at		Cdkn1a	−7.11	Cyclin-dependent protein kinase
GSE6514	1454725_at		Tra2a	−6.89	RNA binding
GSE6514	1417574_at		Cxcl12	−6.86	Growth factor activity
GSE6514	1416749_at		Htra1	−6.84	Insulin-like growth factor binding
GSE6514	1436094_at		Vgf	−6.74	Neuropeptide hormone activity
GSE6514	1420093_s_at		Hnrpdl	−6.73	DNA binding
GSE6514	1451566_at		Zfp810	−6.68	Metal ion binding
GSE6514	1416354_at		Rbmx	−6.56	RNA binding
GSE6514	1448654_at		Mtch2	−6.53	Transport
GSE6514	1439630_x_at		Sbsn	−6.50	Molecular function
GSE6514	1423796_at		Sfpq	−6.48	DNA binding
GSE6514	1441075_at		Nostrin	−6.47	DNA binding
GSE6514	1454014_a_at		Mkks	−6.40	ATP binding
GSE6514	1429862_at		Pla2g4e	−6.38	Phospholipase A2 activity
GSE6514	1428470_at		Exoc2	−6.32	Ral GTPase binding
GSE6514	1426722_at		Slc38a2	−6.28	Amino acid transmembrane transporter activity
GSE6514	1448454_at		Srsf6	−6.22	Negative regulation of mRNA splicing
GSE6514	1417303_at		Mvd	−6.17	ATP binding
GSE6514	1460645_at		Chordc1	−6.12	Hsp90 protein binding
GSE6514	1451047_at		Itm2a	−6.09	Integral membrane protein
GSE6514	1452318_a_at		Hspa1b	−6.09	NF-kappaB binding
GSE2871	AF020212_s_at		Dnm1l	−6.32	Apoptosis, inferred
GSE6514	1417606_a_at		Calr	−6.08	Androgen receptor binding
GSE6514	1452170_at		Chpf2	−6.06	Molecular function
GSE6514	1428112_at		Manf	−6.06	Growth factor activity
GSE6514	1435158_at		Rbm12b1	−6.04	RNA binding
GSE2870	1369751_at	0.00002325	TRHR thyrotropin releasing hormone receptor	−6.17	Thyrotropin releasing hormone receptor, GPCR signaling pathway
GSE2871	rc_AI172162_at	0.0000257	Psmb4	−6.01	Negative regulation of inflammatory response to antigenic stimulus
GSE2870	1367851_at	0.00005068	Prostaglandin D2 synthase	−6.00	Regulation of circadian cycle
GSE2392	1427660_x_at	0.00038711	IGK-V28	−6.04	Response to lipopolysaccharide

(b)

Set 1	ID (set 1)	value (adjusted), set 1	Gene symbol	Set 2	ID (set 2)	value (adjusted), set 2	Broad function
GSE96	35670_at		Atp1a3	GSE2871	D00189_at		Dystonia in mice
GSE6514	1438635_x_at		B930041F14Rik	GSE19185	ILMN_1250201		Channel activity
GSE2871	AF055884_s_at		Deaf1	GSE6514	1448446_at		Zinc finger transcriptional regulator, SPN
GSE96	40422_at		IGFBP2	GSE19185	ILMN_2930897		Insulin-like growth factor binding protein
GSE6514	1422660_at		Rbm3	GSE19185	ILMN_1234453		RNA binding
GSE96	39756_g_at		Xbp1	GSE6514	1437223_s_at		MHC class 2 regulation