Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

Table 4

Tests of overall positive selection of VGF protein using CODEML of PAML.

Model	ln L	Parameter estimates	−2Δln L	Positively selected sites
M0 (one-ratio)	−22230.135
M3 (discrete)	−21925.088	= 0.308; = 0.031; = 0.580; = 0.272; = 0.112; = 0.763	n.s.
M1a (neutral)	−22088.358	= 0.870; = 0.184; = 0.131; = 1.000
M2a (selection)	−22088.358	= 0.869; = 0.184; = 0.089; = 1.000; = 0.042; = 1.000	n.s.
M7 (beta)	−22007.790	= 0.843, = 2.462
M8 (beta&ω > 1)	−22005.004	= 0.976; = 0.955; = 3.090; = 0.024; = 1.054	n.s.	499, 501, 512, 576, and 579; 442, 505, and 518

log-likelihood; likelihood ratio test (LRT) for detection of positive selection; sites inferred to be under positive selection pressure posterior probability by BEB method; sites inferred to be under positive selection pressure posterior probability by NEB method; not significant.