Research Article
Prognostic Value of Osteopontin Splice Variant-c Expression in Breast Cancers: A Meta-Analysis
Table 1
General characteristics of included studies.
| | First authors | Journal | Year | Country | Number of patients | Follow-up (months) | Index | Methods | Cut-off point (high/low) | OPN+/OPN− | HR estimation | Quality assessment (0–9) |
| 1 | Anborgh [3] | Am J Transl Res | 2015 | UK | 53 | 76 | OPN | ELISA | Median | 31/22 | HR + 95% CI | 7 | 2 | Martinetti [4] | Endocrine-Related Cancer | 2004 | Italy | 34 | 60 | OPN | ELISA | Median | 12/22 | Survival curves | 8 | 3 | Singhal [5] | Clin Cancer Res | 1997 | Canada | 70 | 19 | OPN | ELISA | >203 | 24/46 | Survival curves | 7 | 4 | Tuck [6] | Int. J. Cancer | 1998 | Canada | 154 | 195.6 | OPN | IHC | Score > 4 | 11/143 | Survival curves | 5 | 5 | Rudland [7] | Cancer Res | 2002 | UK | 333 | 228 | OPN | IHC | >5% | 221/112 | RR + 95% CI | 8 | 6 | Liao [8] | Modern Oncology | 2010 | China | 70 | 110 | OPN | IHC | Score ≥ 2 | 51/19 | Survival curves | 5 | 7 | Ortiz-Martínez [9] | Human Pathology | 2014 | Spain | 309 | 302 | OPN/OPN-c | qRT-PCR | FC > 32 | 76/231 70/204 | DFS + OS | 7 | 8 | Pang [10] | Cancer Epidemiology | 2013 | China | 170 | 92 | OPN-c | IHC | Score ≥ 2 | 119/51 | HR + 95% CI | 6 | 9 | Zduniak [11] | British Journal of Cancer | 2015 | USA | 291 | 60 | OPN-c | IHC | Score ≥ 2 | 181/110 | Survival curves | 7 | 10 | Patani [12] | Anticancer Research | 2008 | UK | 83 | 150 | OPN-c | qRT-PCR | NPI | 21/62 | OS | 6 |
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