Prognostic Value of Osteopontin Splice Variant-c Expression in Breast Cancers: A Meta-Analysis

Table 1

General characteristics of included studies.

First authors

Journal

Year

Country

Number of patients

Follow-up (months)

Index

Methods

Cut-off point; (high/low)

OPN+/OPN−

HR; estimation

Quality; assessment (0–9)

1

Anborgh [3]

Am J Transl Res

2015

UK

53

76

OPN

ELISA

Median

31/22

HR + 95% CI

7

2

Martinetti [4]

Endocrine-Related Cancer

2004

Italy

34

60

OPN

ELISA

Median

12/22

Survival curves

8

3

Singhal [5]

Clin Cancer Res

1997

Canada

70

19

OPN

ELISA

>203

24/46

Survival curves

7

4

Tuck [6]

Int. J. Cancer

1998

Canada

154

195.6

OPN

IHC

Score > 4

11/143

Survival curves

5

5

Rudland [7]

Cancer Res

2002

UK

333

228

OPN

IHC

>5%

221/112

RR + 95% CI

8

6

Liao [8]

Modern Oncology

2010

China

70

110

OPN

IHC

Score ≥ 2

51/19

Survival curves

5

7

Ortiz-Martínez [9]

Human Pathology

2014

Spain

309

302

OPN/OPN-c

qRT-PCR

FC > 32

76/231; 70/204

DFS + OS

7

8

Pang [10]

Cancer Epidemiology

2013

China

170

92

OPN-c

IHC

Score ≥ 2

119/51

HR + 95% CI

6

9

Zduniak [11]

British Journal of Cancer

2015

USA

291

60

OPN-c

IHC

Score ≥ 2

181/110

Survival curves

7

10

Patani [12]

Anticancer Research

2008

UK

83

150

OPN-c

qRT-PCR

NPI

21/62

OS

6